Ethyl salicylate

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Product Description

Ethyl salicylate's cas code is 118-61-6

Product Detail

Ethyl salicylate Basic information

Product Name:	Ethyl salicylate
CAS:	118-61-6
MF:	C9H10O3
MW:	166.17
EINECS:	204-265-5
Product Categories:	Aromatic Esters;Heterocyclic Compounds;Pharmaceutical Intermediates
Mol File:	118-61-6.mol

Ethyl salicylate Chemical Properties

Melting point	1 °C(lit.)
Boiling point	234 °C(lit.)
density	1.131 g/mL at 25 °C(lit.)
vapor pressure	0.05 mm Hg ( 25 °C)
FEMA	2458 \| ETHYL SALICYLATE
refractive index	n20/D 1.522(lit.)
Fp	225 °F
storage temp.	Store below +30°C.
solubility	0.25g/l
pka	9.93±0.10(Predicted)
form	Liquid
color	Clear colorless to pale yellow
explosive limit	1.1%(V)
Water Solubility	slightly soluble
JECFA Number	900
Merck	14,3850
BRN	907659
InChIKey	GYCKQBWUSACYIF-UHFFFAOYSA-N
CAS DataBase Reference	118-61-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2-hydroxy-, ethyl ester(118-61-6)
EPA Substance Registry System	Ethyl salicylate (118-61-6)

Ethyl salicylate Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/38-52/53
Safety Statements	26-36
WGK Germany	1
RTECS	VO3000000
TSCA	Yes
HS Code	29182390
Toxicity	LD50 orally in Rabbit: 1320 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Ethyl salicylate Usage And Synthesis

Description	Ethyl 2-hydroxdybenzoate is also known as Ethyl salicylate, which a kind of ester formed through the condensation between salicylic acid and ethanol. It can be used as a perfumery, artificial essence flavoring agent and used in cosmetics. It can also be used as analgesics, anti-inflammatory and antipyretic agents.
Chemical Properties	clear colourless to pale yellow liquid
Chemical Properties	Ethyl salicylate is the ester formed by the condensation of salicylic acid and ethanol. It is a clear liquid that is sparingly soluble in water, but soluble in alcohol and ether. It has a pleasant odor resembling winter green and is used in perfumery and artificial flavors.
Chemical Properties	Ethyl salicylate has a characteristic aromatic odor similar to wintergreen. It tends to darken on exposure to light and air.
Uses	manufacture of artificial perfumes.
Production Methods	Ethyl salicylate is found naturally in currants and strawberries . It is manufactured commercially by the esterification of salicylic acid with ethyl alcohol.
Preparation	By esterification of salicylic acid with ethyl alcohol and concentrated H2SO4 at 100°C in the presence of aluminum sul[1]fate; by heating to the boil an alkaline solution of salicylic acid and ethyl p-toluenesulfonate.
Taste threshold values	Taste characteristics at 10 ppm: sweet, wintergreen, spicy and anisic.
References	Sheu, Yaw-Wen, and Chein-Hsiun Tu. "Densities and viscosities of binary mixtures of ethyl acetoacetate, ethyl isovalerate, methyl benzoate, benzyl acetate, ethyl salicylate, and benzyl propionate with ethanol at T=(288.15, 298.15, 308.15, and 318.15) K." Journal of Chemical & Engineering Data 51.2 (2006): 545-553. Filippa, Mauricio, Matías I. Sancho, and Estela Gasull. "Encapsulation of methyl and ethyl salicylates by β-cyclodextrin: HPLC, UV–vis and molecular modeling studies." Journal of pharmaceutical and biomedical analysis 48.3 (2008): 969-973.